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Hexahydrocannabinols (HHCs) represent an emerging class of cannabinoid compounds that have recently attracted the attention of the scientific community and regulatory authorities. These compounds, although found in trace amounts in cannabis, can also be synthesized artificially. HHC was first identified in the 1940s, but has recently come under intense scrutiny due to its rapid market diffusion and potentially harmful effects..
HHC was first discovered by Roger Adams in the 1940s, when he synthesized HHC from the naturally occurring THC in cannabis. Since then, several synthesis methods have been developed, using different precursors like citronellal, olivetol and other similar compounds. HHC can also be produced from different cannabinoids such as THC or CBD. A particularity of HHC is the absence of double bonds in the cyclohexyl ring, which distinguishes it from other cannabinoids.
HHC showed an affinity for CB1 cannabinoid receptors, although this affinity was lower than that of THC. This suggests that HHC is less psychoactive than THC, although it may still produce adverse effects in users. Due to its presence in cannabis plants, it is likely that humans have been unknowingly consuming small amounts of this cannabinoid for centuries..
Despite its presence in cannabis, HHC is now subject to regulatory restrictions in many countries, including France. In June 2023, the National Agency for the Safety of Medicines and Health Products (ANSM) banned the production, sale and use of HHC and its derivatives on French territory. This decision was motivated by the potential harmful effects of HHC and its derivatives, as well as their rapid diffusion on the market.
Hexahydrocannabinol should not be confused with the related compounds 9-Nor-9β-hydroxyhexahydrocannabinol (9-Nor-9Beta-HHC) or 9-Hydroxyhexahydrocannabinol (9-OH-HHC) or 11-Hydroxyhexahydrocannabinol (11-OH-HHC and 7-OH-HHC), all of which have sometimes been called "HHC"
Hexahydrocannabinols represent a new class of cannabinoid compounds that are attracting increasing interest from the scientific community and regulators. Their discovery, synthesis, and effects raise important questions about the safety and regulation of cannabis products. It is essential to continue studying these compounds to fully understand their impact on human health and to develop appropriate regulatory policies..
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